Author(s): P. Neeraja*, M.Amaleshwari and G.Raval
Multiple emulsions are used to enhance bioavailability of various drugs and as a prolong drug delivery system. Multiple emulsions often stabilized using a combination of hydrophilic and hydrophobic surfactants. The ratio of these surfactants is important in achieving stable multiple emulsions. In this study, multiple emulsion of Nifedipine was prepared by two step emulsification method using different surfactants such as tweens and spans. The multiple emulsion is evaluated for stability, percentage drug entrapment and in -vitro drug release. FT-IR studies indicated that there is no chemical interaction in the mixtures. The in-vitro dissolution studies have shown that F3 formulation has higher release profile as compare to other formulation. As the concentration of span 40 increases, the release profile of the formulation was improved.Hence it is concluded that the multiple emulsions are useful for the improvement of dissolution rate and thereby oral bioavailability of poorly water soluble drug Nifedipine.