Author(s): A. Anil kumar, M. Sujatha kumari, K. Surekha, ChSS. Prasad and S. Suresh
The present study was aimed to develop antihypertensive sustained release matrix tables of valsartan Angiotensin II receptor antagonist, using natural polymers (guargum and pectin) as the matrix material in different proportion by direct compression method.the tablets were prepared by Guargum diffrent formulations FG1,FG2,FG3(1:0.5,1:1,1:1.5) and same as with Pectin different formulations FP4,FP5,FP6 (1:0.5,1:1,1:1.5) . The tablets were subjected to weight variation test, drug content, hardness, friability, and in vitro release studies.. In vitro dissolution studies indicate that among all the formulations FG3 (1:1.5) significantly reduced the rate of drug release compared to other formulations. The result of dissolution study indicate that the formulation prepared by guargum (1:1.5) ratio showed maximum drug release up to 23 hrs. Methematical treatment of the in vitro drug release data suggest that, optimized formulation FG3 fitted in to zero order and Peppas release kinetic shows R2 value 0.982. Drug release from the matrix occurred by combination of two mechanism, diffusion and erosion of tablet. So when compared to Pectin the Guargum is the best polymer to control the release of Valsartan tablet.