Author(s): K.Kavitha*, Narendra Chary T., G.Rajesh, S.Ramesh, S.Shivaleela, P.Lavanyaand Premalatha
Formulation of floating drug delivery system is to increase the safety of the drug and to extend its duration of action. This novel drug delivery system is essential for the drugs that are degraded in the intestine. This floating drug delivery system is aimed at providing increased bioavailability. Floating drug delivery system can be retained in the stomach for long time by formulating Ranitidine with low density polymers like hydroxyl propyl methyl cellulose and gas generating agents are added to the system to reduce the density of the system. Intimate contact of the drug with the absorbing membrane has the potential to maximize the drug absorption. The controlledrelease of drug is according to the physiological state of the subject and design of the pharmaceutical formulation. Formulation was optimized on the basis of floating time and in-vitro drug release. The tablet was subjected to evaluation for physical characteristics like weight variation, hardness, friability, drug content uniformity, floating lag time, total floating time and in-vitro drug release. Four different formulations of ranitidine were formulated by variation in the ratio of hydroxyl propyl methyl cellulose. From the investigation it’s found that Ranitidine incorporated with concentration of 33% of HPMC was found to be better formulation by considering all the evaluated parameters like floating lag time, total floating time, hardness, friability and weight variation and percentage drug release.