ISSN: 2249-9504
CAS CODEN: IJPCDX

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Citations : 3566

International Journal of Pharmaceutical, Chemical and Biological Sciences received 3566 citations as per google scholar report

International Journal of Pharmaceutical, Chemical and Biological Sciences peer review process verified at publons

FORMULATION AND EVALUATION OF PULSATILE DRUG DELIVERY SYSTEM OFFLURBIPROFEN

Abstract

Author(s): G. Rama Krishna, K. Neelima,D.Srinivasa Rao andS.Ramu

Aimof thepresentworkwastoformulateandevaluateanoralpulsatile drug delivery system to achieve time release of flurbiprofen, based on Chronopharmaceuticalapproachfor thetreatmentof antiinflammatory agent.Pulsatiledelivery systemiscapableof delivering drugwhenandwhereitrequiredmost.Time-delayedtablets,designedto releasedrugafterapredictablelagtime, areintended fororal chronotherapy.Thebasicdesignconsistsofacoretabletspreparedby wetgranulationmethod. Thetabletswerecoatedwithaninnerswellablelayercontaining karaya gum and sodium alginate.Theentire devicewasentericcoatedwith3% celluloseacetatephthalatesolution,sothatthevariabilityingastricemptyingtimecanbe overcome.Thepreparedpulsatiletabletswereevaluatedforthedrug content,thickness and in-vitro releaseprofile, etc. In-vitroreleaseprofilesofpulsatiledeviceduring sixhoursstudieswerefoundto havevery goodsustainingefficacy.During thefirstfivehoursitshowsminimumdrug releaseandattheendofsixhoursimmediatereleasewasobserved.Increasingthelevel of therupturablelayer increasedmechanicalstrengthandretardedthewater uptake and thus prolonged the lag time. Stability studiesprovedthat coatingof tabletsseemstodecrease theeffectof temperature andmoisture onthe degradation of flurbiprofen.Theprogrammablepulsatilereleasehasbeenachievedfromtabletovera 7-8 hr period, consistent with thedemands ofchronotherapeuticdrugdelivery

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