ISSN: 2249–9504
CAS CODEN: IJPCDX

FORMULATION AND EVALUATION OF GASTRORETENTIVE CLARITHROMYCIN FLOATING TABLETS

Abstract

Author(s): S.Ramu*, A.Suneetha Devi, D.SrinivasaRao and Ramakrishna G

The objective of the present study is to “optimize, formulate and evaluate the gastro retentive Clarithromycin Floating tablets”. Clarithromycin is a broad spectrum antibiotic. It has high absorption in the upper part of GIT. It has low oral bioavailability. The GRDDS is able to prolong the retentive time of a dosage form in the stomach, thereby improving the oral bioavailability of the drug. The Preparation contains 15 formulations by using different polymers like HPMC K4M, HPMC K15M, HEC and HPC polymers are used. The prepared batches of Gastroretentive clarithromycin tablets can be evaluated forpre compression parameters likebulk density, tapped density, carr’s index, hausner`s ratio, and angle of repose and physical evaluation of tablets like weight variation, thickness, hardness test, Floating lag time, dissolution studies. Formulation FHM8has given better controlled drug release and floating properties in comparison to the other formulations. It can be concluded that increase in the sodium bicarbonate concentration decreases the floating lag time and increases the floating time

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