ISSN: 2249–9504
CAS CODEN: IJPCDX

FORMULATION AND EVALUATION OF FLOATING MICROSPHERES OF ROSIGLITAZONE

Abstract

Author(s): S.Ramu*, P.Suresh, D.SrinivasaRao and G.Ramakrishna

The goal in designing floating drug delivery systems (FDDS) or hydrodynamically balanced systems have a bulk density lower than gastric fluids and therefore remain floating in the stomach without affecting the gastric-emptying rate for a prolonged period. The objective of the study is to formulate and evaluate Rosiglitazone floating microspheres by ionotropic gelation method.The Preparation contains nine formulations using different polymers i.e. Xanthan gum and Guargum in different ratios. The prepared batches of Rosiglitazone floating microspheres were evaluated formicromeritic studies like bulk density, tapped density, carr’s index (ci), hausner’s ratio, angle of repose,and evaluation studies likein vitro buoyancy, swelling index,drug entrapment efficiency and in-vitrorelease studies. All the formulations were evaluated for bulk density, tapped density, % compressibility, hausner’s ratio and angle of repose the results show that the formulations have very good flow properties. Percentage Drug entrapment efficiency of Rosiglitazone arranged from 56to72%for microspheres containing sodium alginate along with guargum as copolymer, 80 to 82% formicrospheres containing sodium alginate along with xanthum as copolymer.TheformulationsF7, F8, and F9 containingSodiumalginate alongwithXanthumascopolymershoweda maximumreleaseof85.2% at 10thhour,86.2 %at 12thhour, 71.2% at 12thhour respectively.The satisfactory results were obtained in all prepared formulations and based on the results F8 was the best one when compared to other

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