Author(s): Santhosh R Iyer*, R.Sivakumar, P.Siva and CI.Sajeeth
Solubility is an important physicochemical factor affecting absorption of drug and its therapeutic effectiveness. Consequences of poor aqueous solubility would lead to failure in formulation development. The poor solubility of drug substances in water and their low dissolution rate in aqueous G.I.T fluid often leads to insufficient bioavailability. In the present investigation, an attempt was made to improve the solubility and dissolution rate of a poorly soluble drug, Risperidone by solid dispersion method using Beta-cyclodextrin, crospovidone and croscarmellose as carrier with varying drug: carrier ratios. The solid dispersions were formulated as fast dissolving tablets by using Doshion P544 resin (C), a taste masking agent with different superdisintegrants such as Croscarmellose and crospovidoneand were subjected to various pre formulation and post formulations studies. All the formulations showed marked improvement in the solubility behaviour and improved drug release. The results concluded that fast dissolving tablets of poorly soluble drug, Risperidone showed enhanced dissolution, may lead to improved bioavailability and hence better patient compliance.