Abstract
Author(s): Nagakanyaka Devi Paladugu1*,Bonthu Satyanarayana1,Neerukonda Vamsi1,ShaikIrfan Pasha1,Deepthi Poloju2, MD Arief 3, M Rajeev Kumar1and Shaik Wajid Pasha1
Flurbiprofen is a potent non-steroidal anti-inflammatory drug that can be used for rheumatoid arthritis, osteoarthritis, alkylosing spondylitis, tendinitis etc. Its shorter biological half life (3 –4.5 hrs) necessitates it to be administered in frequent doses of 50 –100mg two to four times a day. The main objective of this study was to develop suitable microparticulate system of Flurbiprofen for controlled release delivery system by varying the sodium alginate, PEG 6000 and HPMC concentrations. In the present work Flubriprofen microbeads were formulated using sodium alginateby ionotropic gelation technique. Prepared beads were evaluated for granulometric studies, micromeretic, scanning electron microscopy, drug entrapment efficiency and in-vitro dissolution studies etc. The prepared beads were free flowing and white in colour. The drug loaded beads showed 87.5–98.8 % drug entrapment, which was found to increase with increase in sodium alginate, HPMC, PEG 6000 concentration. Scanning electron microscopy revealed that the beads were almost spherical and rough in structure. Theflow property of the all the batches of prepared microbeads were estimated by angle of repose and found to be in the range of 24050? –33020?In vitro drug releasestudy of these microbeads indicated controlled release of Flurbiprofen, formulations showeda release of 73.67-93.5% at the end of 10 h. Hence from the observation of all results of the different batches fourth and fifth showed controlled release action and improved drug availability. The release of Flurbiprofen was found to be affected by concentration of polymers such as sodium alginate, PEG 6000 and HPMC By the observation of accelerated stability studies fourth and fifth batch formulations were found to be the best formulations. From this study, it could be concluded that the spherical and free flowing microbeads of Flurbiprofen could be successfully prepared by ionotropic gelation technique with high entrapment efficiency and controlled release characteristics.