ISSN: 2249–9504
CAS CODEN: IJPCDX

EVALUATION OF IN VITRO ANTI INFLAMMATORYACTIVITY OF ELAEOCARPUS GANITRUS OF BARK EXTRACT BY HRBC MEMBRANE STABILIZATION

Abstract

Author(s): M. Arya Lakshmi*, K. Srinivas, S. Usha Rani and Praneetha. V

To evaluate the in-vitro anti inflammatory activity of Elaeocarpus ganitrus roxb of bark extracts by HRBC membrane stabilization. The plant Elaeocarpus ganitrus roxb (Elaeocarpaceae) commonly known as Rudraksha the king of herbal medicines. The plants are distributed throughout India, Southeast Asia, Japan, Malaysia, Southern China, Australia etc. The leaves, fruits, seeds and stems of the plant have been used widely in traditional folk medicine in many parts of India. In the information regarding the use of bark of Elaeocarpus ganitrus Roxb for several disorders systemic in vitro studies were carried out in our laboratory to establish the anti inflammatory potential by using HRBC membrane stabilization method. HRBC membrane is equals to lysosomal membrane which plays the role in the process of inflammation. The in-vitro HRBC membrane stabilization method showed significant anti inflammatory property of various Elaeocarpus ganitrus tested extracts. It was found that the chloroform extract shows significant anti inflammatory activity at the concentration of 500µg/ml which is comparable to the standard Diclofenac sodium.

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