Abstract
Author(s): M.Hima Bindu1*, Venkateswarlu Guddeti2, T.Kala Praveen3, P.Sri Lakshmi Surekha1,M.Gayathri4, VS.Prakash Allam4and Ch.Radha
Inflammationis a localized reaction that produces redness, warmth, swelling, and pain as a result of infection, irritation, or injury. Inflammation can be external or internal. In traditional system of medicine Musa Paradisiaca(Linn.)leaves The fruits are sweet, astringent, emollient, Cooling, anthelmintic, aphrodisiac, antiscorbutic, demulcent and tonic. The leaves are good for scabies and inflammations.Hence, the present study was aimed to explore the possible anti -inflammatory activity of leaves extract ofMusa Paradisiaca(Linn.)in experimental animal models. For assessing of anti -inflammatory activity carrageenan induced paw edema model was used. Diclofenac was used as a standard reference for this model. Shade dried leaves of Musa Paradisiaca(Linn.)were powdered and subjected to Soxhlet extraction using alcohol and water. Hydroalcoholic extract was administered to the animals as suspension using 2%gum acacia for experimental purpose. Preliminary photochemical investigation of the hydroalcoholic extract of Musa Paradisiaca(Linn.)leaves reveals the presence ofcarbohydrates, flavonoids, Alkaloids, phytosterols, fats and oils. Hydroalcoholic extractof Musa Paradisiaca(Linn.)leaves either up to the dose level of 2000 mg/kg did not produce any sort of mortality. However, the physical activity of the animals was reduced. In the treatment of carrageenan induced paw edema in rats, there was highly significant decreased paw volume when treated with Diclofenac and high dose of Musa Paradisiaca leaves extract. This activity may be due to presence of flavonoids, phytosterols and tannins in extract.