ISSN: 2249–9504
CAS CODEN: IJPCDX

ETHOSOMES: A NOVEL APPROACH TO ENHANCEMENT THE BIOAVALIABILITY OF POORLY SOLUBLE DRUGS

Abstract

Author(s): Rajni Karakoti*, Vikas Bhatt, Arun Kumar Singh and Dinesh Kumar Sharma

Ethosomes are novel carrier systems used for delivery of drugs that have low penetration through the biological membrane mailny skin. Ethosomes are soft and malleable lipid vesicles containing phospholipid, high proportion of alchol and water, to enhance the delivery of active pharmaceutical agents. Ethosomes have higher penetration rate through the skin as compared to the liposomes. The increase permeation of ethosomes is due to its higher ethanolic content, are able to encapsulate and deliver the highly water soluble drug through the skin. Ethosomes provide a number of important benefits including improving the drug efficacy, enhancing bioavaliability, patient compliance and reducing the total cost of treatment. Enhance delivery of bioactive components through the skin and cellular membrane by an ethosomal novel carrier opens numerous challenges and opportunities for the research and future development of novel improved therapies

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