ISSN: 2249–9504
CAS CODEN: IJPCDX

EFFECTS OF CLONIDINE ON HAEMODYNAMICS IN PATIENTS UNDERGOING LAPAROSCOPIC CHOLECYSTECTOMY-A COMPARATIVE STUDY

Abstract

Author(s): Sushil Kumar Nayek1,Mohua Sengupta2*,Kalyan Kumar Paul3, Dhurjoti Prosad Bhattacharjee1and Suhrita Paul2

A randomized double blind prospective trial designed to evaluate the efficacy of clonidine in achieving haemodynamic stability in patientsundergoing laparoscopic cholecystectomy. Sixty patients, of both sex (31-60 yrs of age) undergoing elective laparoscopic cholecystectomy were randomly allocated equally in one of the two parallel groups: C & P. Group C received clonidine 1.5 μg /kg intravenously over a period of 15 minutes before induction followed by 1 μg/kg /hr by continuous i.v. infusion. Group P received isotonic saline 0.9% in the same volume. Mean arterial pressure and heart rate in Group C was significantly less after intubation andthroughout the period of pneumoperitonium. No significant difference in the parameters of recovery was observed between the two groups. Clonidine improves intra and post-operative haemodynamic stability during laparoscopic surgery without prolonging recovery

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