ISSN: 2249-9504
CAS CODEN: IJPCDX

Abstracted and Indexed

open access publisher, open access publishing, open access journals and articles, peer reviewed open access journals, insight medical publishing open access publisher, open access publishing, open access journals and articles, peer reviewed open access journals, insight medical publishing open access publisher, open access publishing, open access journals and articles, peer reviewed open access journals, insight medical publishing open access publisher, open access publishing, open access journals and articles, peer reviewed open access journals, insight medical publishing open access publisher, open access publishing, open access journals and articles, peer reviewed open access journals, insight medical publishing open access publisher, open access publishing, open access journals and articles, peer reviewed open access journals, insight medical publishing open access publisher, open access publishing, open access journals and articles, peer reviewed open access journals, insight medical publishing open access publisher, open access publishing, open access journals and articles, peer reviewed open access journals, insight medical publishing open access publisher, open access publishing, open access journals and articles, peer reviewed open access journals, insight medical publishing open access publisher, open access publishing, open access journals and articles, peer reviewed open access journals, insight medical publishing open access publisher, open access publishing, open access journals and articles, peer reviewed open access journals, insight medical publishing open access publisher, open access publishing, open access journals and articles, peer reviewed open access journals, insight medical publishing open access publisher, open access publishing, open access journals and articles, peer reviewed open access journals, insight medical publishing open access publisher, open access publishing, open access journals and articles, peer reviewed open access journals, insight medical publishing open access publisher, open access publishing, open access journals and articles, peer reviewed open access journals, insight medical publishing open access publisher, open access publishing, open access journals and articles, peer reviewed open access journals, insight medical publishing open access publisher, open access publishing, open access journals and articles, peer reviewed open access journals, insight medical publishing open access publisher, open access publishing, open access journals and articles, peer reviewed open access journals, insight medical publishing open access publisher, open access publishing, open access journals and articles, peer reviewed open access journals, insight medical publishing open access publisher, open access publishing, open access journals and articles, peer reviewed open access journals, insight medical publishing
+32 25889658
Google Scholar citation report
Citations : 3566

International Journal of Pharmaceutical, Chemical and Biological Sciences received 3566 citations as per google scholar report

International Journal of Pharmaceutical, Chemical and Biological Sciences peer review process verified at publons

EFFECT OF MANUFACTURING VARIABLE ON DESIGNING OF EXTENDED RELEASE TABLET OF ETODOLAC USING KOLLIDON? SR

Abstract

Author(s): Arun Kumar Arumugarajan1*, G. Geetha2and Bhabani Shankar Nayak3

Background:The drug Etodolac, is a non-steroidal anti-inflammatory drugs (NSAIDs) prominently used for treatment of chronic rheumatism.Aims: The objective of the present study to evaluate theeffect of manufacturing process variable on designing of extended release tablet of Etodolac using natural polymer. Materials and Methodology:Etodolac control release tablets were prepared by direct compression and wet granulation methods using Kollidon® SR (Semi-synthetic polymer) in different ratios (7, 8, 9 and 10 %) as release rate controlling polymers. The granules were evaluated for flow properties by evaluating bulk density, tapped density, Carr’s index, Hausner’s ratio and angle of repose. The tablets were evaluated for drug polymer compatibility study by FTIR, diameter, weight variation test, hardness, friability, disintegration test, in vitrodrug release, release kinetics and stability studies. Results and Discussions:The FTIR study revealed that no such interactions being taking place in between drug and polymers. The flow property of granules of all tablet batches was found to be good. All the tablet formulations had good tablet physiochemical properties. All Etodolac extended release tablet formulations showed satisfactory drug content and in vitrorelease. Conclusion:The results of in vitrostudy, it was concluded that Etodolac matrix tablet containing Kollidon® SR(10.0 %) prepared bywet granulation method, provided most controlled release of water-soluble Etodolac over extended period of time. Thus wet granulation method is the optimized method in designing of extended release tablet of Etodolac.

Get the App

Global Tech Summit