ISSN: 2249-9504
CAS CODEN: IJPCDX

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Citations : 3566

International Journal of Pharmaceutical, Chemical and Biological Sciences received 3566 citations as per google scholar report

International Journal of Pharmaceutical, Chemical and Biological Sciences peer review process verified at publons

DEVELOPMENT, CHARACTERIZATION AND OPTIMIZATION OF SOLID LIPID NANOPARTICLES FROM MICROEMULSION TECHNIQUE USING A BOX-BEHNKEN DESIGN

Abstract

Author(s): M. Parvathi1*,J. Raveendra Reddy1andD. SubbaRao2

The objective of this study wasto formulate and optimize PA loaded SLNs usingvarious solid lipids. The SLNs were prepared from phase behaviours of hot microemulsions-ultra probe sonication technique.The phase diagrams were prepared from lipid/Smix at 60oc using prosimsoftware. The analogy between design factors and experimental data was studied using response surface methodology(RSM). A statistical technique of RSM with Box-Behnken design wasframed to study and determine the influence of formulation independent factors including a solidlipid (x1), surfactant/co-surfactant ratio (x2), sonication time (x3). The dependent factors were particle size, entrapment efficiency(%EE). Tristearin showed better stability and low particle size hence selected for the study. The prepared nanoparticles were in a spherical shape and average particle size of 24.69 nm andthe polydispersity index, zeta potential and %EE range of -0.274, -28.47mV & 89.82% respectively. In Vitro diffusion studies showed a burst release at the initial stage followed by prolonged release of PA from SLNs up to 15hrs and drug diffusion found to be 94.85%. The release kinetics of the optimized formulation was best fitted the zero order model (R2-0.9938).These results concluded that the prednisolone acetate loaded SLNs could potentially be exploited as a delivery system with improved drug entrapment efficiency, low mean particle size and controlled drug release.

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