ISSN: 2249-9504
CAS CODEN: IJPCDX

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Citations : 3566

International Journal of Pharmaceutical, Chemical and Biological Sciences received 3566 citations as per google scholar report

International Journal of Pharmaceutical, Chemical and Biological Sciences peer review process verified at publons

DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR THE ESTIMATION OF PROPOFOL IN BULK AND PHARMACEUTICAL FORMULATIONS

Abstract

Author(s): SM. Anil Kumar1*, A. Satish Kumar Shetty1 and ND. Satyanarayan

The objective of the current study was to develop a simple, accurate, precise and rapid RP-HPLC method and subsequently validate as per ICH guidelines for the determination of Propofol using mobile phase acetonitrile and methanol (pH-5.3), in the ratio of 25:75 v/v was considered to be the optimal composition as the solvent. The proposed method involves the measurement of retention time at selected analytical wavelength. 254.0 nm was selected as the analytical wavelength. The retention time of PROP was found to be 3.534 min. The linearity of the proposed method was investigated in the range of 100-500 μg/ml with regression coefficient value of 0.9996. The method was statistically validated for its linearity, accuracy and precision. Both inter-day and intra-day variation was found to be showing less % RSD (Relative Standard Deviation) value indicating high grade of precision of the method.

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