ISSN: 2249-9504
CAS CODEN: IJPCDX

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Citations : 3566

International Journal of Pharmaceutical, Chemical and Biological Sciences received 3566 citations as per google scholar report

International Journal of Pharmaceutical, Chemical and Biological Sciences peer review process verified at publons

DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR THE DETERMINATION OF MONTELUKAST SODIUM IN BULK AND IN PHARMACEUTICAL FORMULATION

Abstract

Author(s): K. Naga Raju, T. Gopala Swamy, A. Lakshmana Rao

A rapid and sensitive RP-HPLC method with UV detection for routine analysis of montelukast sodium in bulk and in pharmaceutical formulation was developed. Chromatography was performed with mobile phase containing a mixture of ammonium acetate buffer and methanol in the ratio of 15:85 v/v with flow rate 1.0 ml/min. In the range of 50-150 µg/ml, the linearity of montelukast sodium shows a correlation coefficient of 0.999. The proposed method was validated by determining sensitivity accuracy, precision, robustness, stability, specificity, selectivity and system suitability parameters.

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