ISSN: 2249-9504
CAS CODEN: IJPCDX

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Citations : 3566

International Journal of Pharmaceutical, Chemical and Biological Sciences received 3566 citations as per google scholar report

International Journal of Pharmaceutical, Chemical and Biological Sciences peer review process verified at publons

DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF EPERISONE HYDROCHLORIDE AND DICLOFENAC SODIUM IN BULK AND PHARMACEUTICAL DOSAGE FORM

Abstract

Author(s): D. Kamble Neelam1*,S. Mahajan Supriya1, S. Pradhan Nitin2, S. Prabhune Swarup2and S. Reddy Sajjalavarlakshmi2

A simple, selective, precise and accurate Reverse Phase High Pressure Liquid Chromatographic (RP-HPLC) method was developed and validated for the simultaneous estimation of eperisone hydrochloride and diclofenac sodium in marketed sustainedrelease (SR) capsules. Themethod was validated foraccuracy,specificity, linearity and robustness as per the ICH guidelines.Theresultsof thedevelopedmethodwerefound to be reproducibleandwithin officiallimits of USP.Isocratic elution at a flowrate of 1.0 mL per min was employed on symmetry C18column at temperature of 10o C. The method was successfully applied to estimate eperisone hydrochloride and diclofenac sodium in marketed SR capsules since there was no interference from the excipients.

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