ISSN: 2249–9504
CAS CODEN: IJPCDX

DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR QUANTITATIVE ANALYSIS OF FAROPENEM IN PURE AND PHARMACEUTICAL FORMULATIONS

Abstract

Author(s): G. Raveendra Babu1, A. Lakshmana Rao2* and J. Venkateswara Rao3

A validated simple, sensitive, specific and precise RP-HPLC method was developed for the determination of Faropenem in pure and pharmaceutical formulations. Method was carried on Inertsil C18 column (150 mm x 4.6 mm, 5 μ particle size) using phosphate buffer:methanol (55:45 v/v) as mobile phase. Detection was carried out by UV at 316 nm. The proposed method obeyed linearity in the range of 80-600 μg/mL and met all specifications as per ICH guidelines. Statistical analysis revealed that this method can be used in routine quality control studies of Faropenem in pure and its pharmaceutical formulations.

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