ISSN: 2249-9504
CAS CODEN: IJPCDX

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Citations : 3566

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DEVELOPMENT AND VALIDATION OF NOVEL HPTLC METHOD FOR THE SIMULTANEOUS ESTIMATION OF ATORVASTATIN CALCIUM AND TELMISARTAN IN TABLET DOSAGE FORM

Abstract

Author(s): TB. Deshmukh* and SS. Deo

A simple, accurate, precise normal phase high performance thin layer chromatography (HPTLC) method was developed and validated for simultaneous estimation of Atorvastatin Calcium (ATC) and Telmisartan (TEL) in tablet dosage form. Chromatographic separation of the drugs was performed on aluminium plates precoated with silica gel 60 F254 as the stationary phase and the solvent system consisted of Chloroform: Methanol: Toluene: Ammonia (5:2:1:0.2 v/v/v/v). Densitometric evaluation of the separated zones was performed at 289 nm. The two drugs were satisfactory resolve with Rf values 0.17 ± 0.02 and 0.49 ± 0.02 for Atorvastatin Calcium and Telmisartan respectively. The linearity was studied in the concentration range 100-600 μg/ml for both Atorvastatin Calcium and Telmisartan with a correlation coefficient of 0.9998 and 0.9997 respectively. The method was validated for linearity, accuracy, precision, LOD, LOQ and robustness as per International Conference on Harmonisation (ICH) guidelines. The study shows that the developed method is repeatable and selective for the estimation of Atorvastatin calcium and Telmisartan in its pharmaceutical formulations.

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