ISSN: 2249–9504
CAS CODEN: IJPCDX

DEVELOPMENT AND OPTIMIZATION OF FIXED DOSE ANTIHYPERTENSIVE COMBINATION DRUGS USING DOUBLE LAYER SUSTAINED RELEASE MICROSPHERE TECHNOLOGY

Abstract

Author(s): Anant Kumar

For the development of Double walled microspheres, we have selected polymer: Chitosan and EudragitE100. The inner core which is made up of polymer chitosan will contain drug; propranolol hydrochloride and outershell which is made up of polymer Eudragit E100 contain; frusemide.Since Eudragit E100 is dissolving below pH5,will release the drug (furosemide) and attain therapeutic plasma concentration, which reduces the body fluid thusalso reduces blood pressure then the inner core chitosan’s is a muco-adhesive, contains propranolol hydrochloride,adhesive to mucous layer of Stomach or GIT will provide the sustain release of the drug for a longer period (24hr).Therefore, it was the goal of present study to adapt methods of double-walled fabrication with modifications, forthe successful encapsulation of water-soluble. Propanolol hydrochloride and water insoluble Furosemide, resultingin reduced-initial bursts as well as sustained release profiles suitable for the treatment of hypertension.

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