ISSN: 2249–9504
CAS CODEN: IJPCDX

DEVELOPMENT AND EVALUATION OF SUSTAINED RELEASE TABLET OF CEFIXIME USING BIOPOLYMER OBTAINED FROM GLYCINE MAX

Abstract

Author(s): Richa Pandey, Gayatri Joshi, Hema Devi Vaishnaw

Cefixime is an antibiotic useful for the treatment of a number of bacterial infections. It is a third
generationcephalosporin. The bactericidal action of cephalosporin is due to the inhibition of cell
wall synthesis. It binds to one of the penicillin binding proteins (PBPs) which inhibit the final
transpeptidation step of the peptidoglycan synthesis in the bacterial cell wall, thus inhibiting
biosynthesis and arresting cell wall assembly resulting in bacterial cell death.
Recently biopolymer was used as material for conventional as well as novel dosage form
development. The biopolymer was isolated from the seed of Glycine max (Soybean) by non
solvent addition method. The merits of biopolymers have over synthetic polymers are low cost,
natural origin, nontoxic, biocompatible, biodegradable, environmental friendly processing, local
availability, better patient tolerance as well as public acceptance. The polymer were subjected to
its physicochemical, phytochemical and micromeritic studies.

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