ISSN: 2249–9504
CAS CODEN: IJPCDX

DEVELOPMENT AND CHARACTERISATION OF ORAL SOFT GEL CONTAINING FLUCONAZOLE USP FOR THE TREATMENT OF ORAL CANDIDIASIS

Abstract

Author(s): C. Sarath chandran1, AV. Chinnumol1, TK. Shahin Muhammed2, KV. Vipin1 and Ann Rose Augusthy1

Fluconazole USP, a synthetic antifungal agent belonging to the group of triazole is one of the most commonly used antifungal agents for treating oral fungal infections, such as oral candidiasis. In order to bypass the disadvantages of solid dosage forms, the oral soft gel formulations may be proposed as better drug delivery tool for treating oral candidiasis. This study was conducted to develop a gel formulation of fluconazole using biodegradable polymers like chitosan and sodium alginate.The gels were evaluated for physical appearance, rheological behaviour, drug release and stability. Among all the gel formulations, chitosan showed superior drug release than sodium alginate. Drug release decreased with increase in polymer concentration. Stability studies showed that the physical appearance, pH and drug content remained unchanged upon storage for 45 days at ambient conditions.

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