Author(s): P.Uday Kumar*, G.Ramakrishna, D.Srinivasa Rao, S.Ramu and D.Varun
Dosage forms that can be retained in the stomach are called gastroretentivedrug delivery systems (GRDDS). GRDDS can improve controlled delivery of drugs with an absorption window by continuously releasing the drug for a prolonged period before it reaches its absorption site, thus ensuring optimal bioavailability. Drugs with a narrow absorption window are mostly associated with improved absorption at the jejunum and ileum due to the enhanced absorption properties of these sites (e.g. large surface area), or because of enhanced solubility in the stomach as opposed to the more distal parts of the GIT. Objective of the present work is to design and evaluate Gastroselective Buoyant Tablets of Cefuroxime axetil. Different formulae were developed by incorporating various polymers.All the developed formulations were subjected to invitrodissolution testing and the data was fitted to various exponential equations in order to assess the exact release mechanism. Compatibility among the drug and polymers was checked by subjecting the samples to FTIR and DSC characterization.