ISSN: 2249–9504
CAS CODEN: IJPCDX

DESIGN AND DEVELOPMENT OF METOPROLOL SUCCINATE PULSINCAP TECHNOLOGY CHRONOTHEREPEUTIC SYSTEM USING NATURAL GUM AS A MATERIAL FOR COLON TARGETING

Abstract

Author(s): Yezihaaz*, M. Kishore Babu, M. Vasavi chandrika, GV. Murali Krishna and K. Naga Phani kumar

The aim of the present study was to develop modified pulsincap drug delivery system containing Metaprolol Succinate for colon specific drug delivery in the management of Angina Pectoris. The IR spectral studies of”Metoprolol Succinate” and different grades of Gum Kondagogu proved that they were compatible. Upon Formaldehyde treatment the size “2” capsule bodies showed a significant decrease in the length and diameter from 18.3 mm to 17.5mm and 6.3mm to 6.1 mm respectively. The untreated caps disintegrated within 15 minutes in the buffer medias such as 1.2, 6.8, 7.4 where as the treated bodies remained intact for about 24 hours. The coating thickness of the capsules varied from 0.0052 mm to 0.0057 mm between the formulations. The formulations containing Gum Kondagogu as a natural polymeric plug-in material showed better colonic release profiles of 101.72% and 99.98% for grade-III (70mg and 75 mg) at 6hrs and 6.5 hrs respectively observed as per the lag time equated for the drug to reach colon when compared to that of gum Kondagogu grade-II where much of the drug released prior reaching to simulated colonic medium. On contrary, the formulations containing HPMC 3000cps showed delayed release profile for more than 7 hrs deviating from the objective. Further the results suggested that the formulation F8 containing gum Kondagogu grade-III (75 mg) showed optimum drug release when compared to the formulation F7 thus specifically adhering to the objective.

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