ISSN: 2249–9504
CAS CODEN: IJPCDX

COMPARATIVE STUDIES ON ANTI-INFLAMMATORY ACTIVITY OF HYDROGELS CONTAINING HERBAL EXTRACTS

Abstract

Author(s): SK.Patil*, VR.Salunkhe,DS.Ghumte, SK.Mohite and CS.Magdum

The main objective of this study is to evaluate and compare anti-inflammatory activity ofhydrogels containing herbal hydro-alcoholic extracts of Pterocarpus marsupium, Pterocarpus santalinus andGlycyrrhizaglabra. Hydroalcoholic solvent ethanol: water in 70:30 proportions was used for the extraction by continuous hot extraction using Soxhlet apparatus. The herbal hydrogels containing 10% extract as API were formulated using chitosan as gel base, by chemical crosslinking of chitosan with glutaraldehyde. Anti-inflammatory activity of herbal hydrogels was evaluated by carrageenan induced rat hind paw edema method. Animals were divided into six group comprising six animals in each group of either sex, for comparing their activity against standard (Enacgel) and control groups. The hydrogel containing hydro-alcoholic extracts of Pterocarpus marsupiumshowed significant anti-inflammatory activity (43.70%) when compared with the standard (17.03%) at the end of 8 hrs and is more significant as that of marketed formulation.

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