Author(s): Sanjay Yadav, Prakash Chandra Gupta*, Nisha Sharma and Jitendra Kumar
Co-crystallization is a new approach of enhancement of solubility, stability, bioavailability and other physicochemical properties. It offers a better optimization of physical and biopharmaceutical properties of drugs. Co-crystal formation involves intermolecular interaction such as Hydrogen bonding, Vander Waals forces and π-π stacking interactions. Robustness of potential intermolecular interaction and hydrogen bonding rules are the important aspects of cocrystallization experiment design. Characterization of co-crystal can be performed by power X-ray diffraction, single crystal X-ray diffraction, infrared spectroscopy, differential scanning calorimetry, scanning electron microscopy, solid state NMR, THz-TDS method. This review covers general consideration of selection of drug for co-crystallization, chemistry of co-crystallization including role of hydrogen bonding in co-crystallization, co-crystal effect on physicochemical properties and characterization of co-crystal using suitable method.