ISSN: 2249-9504
CAS CODEN: IJPCDX

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Citations : 3566

International Journal of Pharmaceutical, Chemical and Biological Sciences received 3566 citations as per google scholar report

International Journal of Pharmaceutical, Chemical and Biological Sciences peer review process verified at publons

COCRYSTALS: AN ALTERNATIVE APPROACH TO MODIFY PHYSICOCHEMICAL PROPERTIES OF DRUGS

Abstract

Author(s): Sanjay Yadav, Prakash Chandra Gupta*, Nisha Sharma and Jitendra Kumar

Co-crystallization is a new approach of enhancement of solubility, stability, bioavailability and other physicochemical properties. It offers a better optimization of physical and biopharmaceutical properties of drugs. Co-crystal formation involves intermolecular interaction such as Hydrogen bonding, Vander Waals forces and π-π stacking interactions. Robustness of potential intermolecular interaction and hydrogen bonding rules are the important aspects of cocrystallization experiment design. Characterization of co-crystal can be performed by power X-ray diffraction, single crystal X-ray diffraction, infrared spectroscopy, differential scanning calorimetry, scanning electron microscopy, solid state NMR, THz-TDS method. This review covers general consideration of selection of drug for co-crystallization, chemistry of co-crystallization including role of hydrogen bonding in co-crystallization, co-crystal effect on physicochemical properties and characterization of co-crystal using suitable method.

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