ISSN: 2249–9504
CAS CODEN: IJPCDX

BIOEQUIVALENCE AND BIOAVAILABILITY STUDY OF ANTIHYPERTENSIVE DRUG: A REVIEW

Abstract

Author(s): Thamke Nita* and Wath Amruta

Drug administered orally or parenterally must reach the general circulation in their pharmacological active form to be distributed throughout the body and to exert therapeutic effect. The intensity of therapeutic actions of many drugs correlate well with the concentration of the drug in the biological fluid. The rate of absorption is therapeutically important in case of narrow therapeutic index drugs, where relatively small changes in the concentration can lead to marked changes in action of drug. Bioavailability and bioequivalence terms related to extend of drug. That determine the pharmacokinetic, pharmacodynamic, pharmacological action of drug

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