Author(s): Geetha Bhaktha1*, Shivananda Nayak1 and Manjula Shantaram2
Adipose tissue functions as an endocrine organ, and also a role in fuel storage, thermal insulation, and mechanical protection, releasing biologically active and diverse cytokines. Exercise is known to increase the insulin sensitivity in muscles. Most of the type 2 diabetes occurs due to life style changes and increased fat accumulation resulting in insulin insensitivity. An increase in physical activity is known to influence the adiponectin, a cytokine that is released from the adipose tissue. Hence, this study was undertaken to understand the effect of regular exercise, on the levels of adiponectin of diabetic subjects. Forty six diabetic subjects who have not exercised regularly and 40 diabetic subjects who exercised regularly were selected. They were matched with the normal healthy 40 subjects who exercised regularly for 1 hour daily and 72 subjects who had not exercised regularly. Adiponectin concentration was estimated using ELISA kit. The results showed better increase in adiponectin levels in diabetic subjects than the normal subjects. Mean value between the normal subjects showed no significant change (p=0.291) within the group but the level was significantly increased in the diabetic group (p=0.0001). Hence with the present study, it is concluded that long term exercising in diabetic subjects was much beneficial in increasing the adiponectin level, hence a decrease in risk factors of cardiovascular disease.