ISSN: 2249–9504
CAS CODEN: IJPCDX

ANTIUROLITHIATIC ACTIVITY OF SOME TRADITIONAL MEDICINAL PLANTS AGAINST CALCIUM OXALATE INDUCED UROLITHIASIS IN RATS

Abstract

Author(s): DG. Baheti* and SS.Kadam

The present study was undertaken to investigate the effects of some traditional medicinal plants i.e Plectranthus mollis Spreng,Didymocarpus pedicellata,Teraxacum officinale,Dendrophthoe elastic desr on experimentally-induced kidneystones. Oxalate urolithiasis in male rats was induced experimentally by administration of 0.75% v/v ethylene glycol with 1% w/v ammonium chloride in drinking water for three days followed by only 0.75% v/v ethylene glycol for 25 days.The petroleum ether extract of Plectranthus mollis Spreng (PM), hydroalcoholic extract ofDidymocarpus pedicellata (DP), ethyl acetate extract of Taraxacum officinale (EA), methanolic extract of Dendrophthoe elastic desr (DE)and, hydroalcoholic extract of Citrus medica Linn (CM)were administered to urolithiasis induced test group rats at two doses i.e. 100 and 200 mg/kg respectively for 28 days.After 28 days, highly significant deposition of calcium oxalate inthe kidneys was noticed along with increase in the urine volume, urinary oxalate, calcium, levels and magnesium levels in urolithiasis control group rats as compared to normal group rats. The serum analysis showed significant increase in the serum uric acid, serum creatinine, andblood ureain urolithiasis control group rats. In addition, vehicle treated induction control group rats showed significant increase in the biochemical parameters such as ACP, ALP, AST, ALT levels and decrease in LDH levels in the kidney homogenate which indicated the induction of urolithiasis.Daily oral treatment with all most all extracts not significantlydecreased the quantity of calcium oxalate deposited in the kidneysbut also reverted all the biochemical changes induced by calcium oxalate urolithiasis thus supporting its traditional claim.Petroleum ether extract of Plectranthus mollis Sprenghowever, wasfound to be insignificant in these regards

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