ISSN: 2249–9504
CAS CODEN: IJPCDX

ANTITUMOR, ANTIOXIDANT AND ANTIBACTERIAL ACTIVITIES OF SECONDARY METABOLITES EXTRACTED BY ENDOPHYTIC ACTINOMYCETES ISOLATED FROM VOCHYSIA DIVERGENS

Abstract

Author(s): DC. Savi*, CWI. Haminiuk, GTS. Sora, DM. Adamoski, J. Kenski, SMB. Winnischofer, C. Glienke

Endophytic actinomycetes encompass bacterial groups that are well known for the production of a diverse range of secondary metabolites, including various antibiotics, antitumor, immunosuppressive agents, plant growth hormones, and have capacity of survive inside of plants tissues. Vochysia divergens is a Brazilian medicinal plant common isolated in the Pantanal region, and was focus of many researches, but the community endophytic remains unknown. Therefore, the goals of the present work were to carry out an initial assessment of antimicrobial, antitumor and antioxidant activities of crude extract produced by endophytic actinomycetes isolated from Vochysia divergens. Using 16S sequences, 10 isolates were classified as Microbispora sp. and two isolates were classified as Streptomyces sampsonii. The other two isolates were identified as Micromonospora sp. and are apparently undescribed species. The isolates were able to produce secondary metabolites with antioxidant activity, antitumor activity against of Glioblastoma cell and antimicrobial activity against bacteria Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Methicillin-Resistant Staphylococcus aureus and the yeast Candida albicans. Taking into consideration the lack of effective medicaments for the treatment of Glioblastoma multiforme, and the increasing number of bacterial strains expressing resistance, the basic research using microorganisms from unexplored environmental showed can be an alternative to discover new secondary metabolites to treat these diseases.

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