ISSN: 2249–9504
CAS CODEN: IJPCDX

ANTIOXIDANT AND ANTI TUMORAL ACTIVITIES OF HYDRAZYLPYRROLIDINE 2, 5 DIONE SUBSTITUTED AND 2-THIOXO IMIDAZOLIDINE 4-ONE

Abstract

Author(s): S. AichoucheBouzroura, L. Salhi, A. Belkebir , O. Ait-Yahia , A. Boudjlida3,S.BouguerraAouichat andB. NedjarKolli

In continuation of our research efforts toevaluate biological properties of synthesized compounds, we have investigated the in vitroantioxidant activity of hydrazylpyrrolidine 2, 5 dione substituted 2, 3and4or 2-thioxo imidazolidine 4-one5,6and7 by spectrophotometric DPPH and lipid peroxide inhibition. The IC50of both compounds was higher excepted compounds 6b, 7a and 4c witch have a low value (4.9, 6.18, 6.70 μg/mL) respectively.Thesecompounds exhibited strong antioxidant activity.Their IC50are approximatively equal to standard quercetin for4c and7a or to ascorbic acid standard for 6b. In vitrolipid peroxydation was determined by antioxidant activity using the β-Carotene/ linoleic acid system. The synthesis compounds have revealed a low or moderate antioxidant activity. The maximum relative antioxidant activity (AAR) was observed for derivatives 2a and7c respectively (53.31, 48.72 μg/mL). In vitro antitumoral activities of compounds 2a and 6b at 370 μg/mLhave exhibited significant antitumoral activities against HEp2(Human Laryngeal CarcinomaCells)

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