ISSN: 2249–9504
CAS CODEN: IJPCDX

ANTI-NOCICEPTIVE ACTIVITIES AND TOXICOLOGICAL PROFILE OF AQUEOUS EXTRACT OF LEAVES OF HIBISCUS ASPER

Abstract

Author(s): TchoumbaTchoumiLilianeMireille, Mbiantcha Marius*, Diffoum Jean Baptiste, Kamanyi Albert

This work was been carried out with the objective of evaluating the anti-nociceptive activities and the toxicological profile of the aqueous extract of the leaves of H.asper. For acute and subchronic toxicity, no case of death was recorded and no modification of behavioral parameters. The relative body weight of rats showed a significant decrease. The weight of the heart of rats treated with all doses showed a significant decrease. The level of ASAT in serum of rats treated with 1000 mg/kg dose showed a significant increase, while the level of hepatic ASAT of rats treated with 250, 500 and 1000 mg/kg doses showed a significant decrease. The analgesic activity of extract on pain induced by acetic acid was significant at doses of 125, 250 and 500 mg/kg with maximum inhibition of 75.14% at the dose of 500 mg/kg. The extract at all doses significantly inhibited the two phases of pain induced by formalin. The analgesic effect of extract on pain induced by pressure was significant at 1h, 2h, 3h and 4h. The analgesic effect of extract on chronic inflammatory pain induced by formalin was significant on the 2nd, 3rd, 4th, 5 thand 7th days of treatment. These results show that the aqueous extract of the leaves of Hibiscus asper can be considered as toxic, and that it possesses analgesic properties. The analgesic properties are at the same time peripheral and central; these analgesic properties could be due to flavonoids and polyphenols contained in the aqueous extract.

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