ISSN: 2249–9504

ANTIDIABETIC ACTIVITY OF NEW IMIDAZOLE DERIVATIVE(2-(2-benzylidenehydrazinyl)-5,5-diphenyl-1,5-dihydro-4H-imidazol 4-one(C22 H17 N4OCl)


Author(s): GE.Suhasini1, M. Nirmala1, DR. Archanagiri2, V.Varalaksmi1andB.Solomon sunder Raj3

The new imidazole chloro derivative was synthesized and evaluated for the nti diabetic activity, by inducing diabetes using alloxan. The study was conducted using rats in four groups with 6 in each. group one served as control, second group served as diabetic control, third group as standard and fourth for test sample. Glibenclamide was used as standard drug . Lipid profile was also studied. The study was conducted for 14 days. Then blood samples were tested on 1st, 3rd, 7th and 14th day. The blood Glucose Levels decreased significantly after the administration of test sample from 449mg/dl to 164mg/dl with p<0. 01 . total cholesterol, LDL cholesterol, triglycerides and VLDL decreased. HDL cholesterol increased. SGPT, SGOT serum glucose levels reduced p<0.01 As the synthesized compound has reduced blood glucose levels and lipid lowering potential this can be developed into hypoglycemic drug.

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