ISSN: 2249–9504
CAS CODEN: IJPCDX

ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF PIPERAQUINE TETRAPHOSPHATE AND DIHYDROARTEMISININ IN COMBINE DOSAGE FORMS

Abstract

Author(s): Prem Kumar Bichala* , Chandra K Maurya, Ravin Yadav, Mohammed Umar, Abul Aziz Dauisa and Auwalu Ibrahim

The proposed method is suitable for the quantitative determination of piperaquine tetraphosphate and dihydroartemisinin in pharmaceutical dosage form. The method provides great sensitivity, adequate linearity and repeatability. The estimation of piperaquine tetraphosphateand Dihydro artemisinin was done by RP-HPLC. The Phosphate buffer was pH 4.6 and the mobile phase was optimized which consists of MEOH: Phosphate buffer mixed in the ratio of 70:30 % v/v. A Symmetry C18 (4.6 x 150mm, 5 m, Make XTerra) column used as stationary phase. The detection was carried out using UV detector at 273 nm

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