Author(s): Nguessom KO, Mbiantcha M*, Ateufack G, Oumar M, Kamanyi A1,2
The aim of this work was to evaluate the analgesics properties and toxicological profile of aqueous extract of the stem barks of Anthocleista vogelii. The analgesics tests were carried out on pain induced by acetic acid and formalin; while the toxicological study related to the acute and sub-chronic toxicity. The extract at 125, 250 and 500 mg/kg, reduced the number of abdominal constrictions induced by acetic acid with 40.42, 65.62 and 68.75 % respectively. In the formalin test, extract provokes 56.48, 59.49 and 89.93 % of inhibition respectively with the same doses; while the second phase is marked by an activity higher of the extract, with 94.16, 97.47 and 100 % of inhibition. In acute toxicity study, the extract was administered orally at doses 0, 4, 8, 16 and 20 g/kg. The animals were observed for any toxic symptoms up to 7 days. The extracts don’t provoke a death until the dose 20 g/kg. The food consumption and the water increases significantly in all animals treated. In a sub-chronic toxicity study, the extract was tested at the dose of 0, 250, 500 and 1000 mg/kg p.o.once daily for 28 days. The body weight and water consumption decreases whereas food consumption increases. The relative organ weight not varies significantly.The serum and hepatic levels of ALT increases significantly, whereas the levels of ASAT, proteins and creatinin (serum and urinary) levels do not vary significantly in all the treated animals compared with the animals of the group controls.