Author(s): NM. Goudgaon* and Rohini Yerram Reddy
Pyrimidine scaffold being an integral part of DNA and RNA, occupy a unique and distinctive role in medicinal chemistry. In the past few years, fluorinated heterocyclic systems have been incorporated into drug discovery research to improve the drug physico-chemical properties. In view of this rational we have synthesized 2-(4-fluorobenzylthio)-N-(substituted phenyl) pyrimidine-4-amines (1a-k) and evaluated them for analgesic and anti-inflammatory activities. The analgesic and anti-inflammatory activities of the synthesized compounds 2-(4- fluorobenzylthio)-N-(substituted phenyl) pyrimidine-4-amines (1a-k) were carried out in albino mice and spruge dawley rats respectively. Compounds 1c and 1f showed good analgesic activity and remaining compounds exhibited moderate to poor analgesic activity when compared to the standard drug Pentazocin. Compounds 1a and 1j showed excellent antiinflammatory activity and compounds 1g, 1h, 1i and 1k showed good anti-inflammatory activity in comparison with the standard drug Diclofenac sodium. Remaining compounds exhibited moderate to poor anti-inflammatory activity. The present study showed that fluorine substituted heterocycles might serve as pharmacologically potent and biologically important drugs.