Author(s): Taseen Gul, Henah Mehraj Balkhi and Ehtishamul Haq*
Obesity, a direct consequence of imbalance between energy intake and expenditure by the body has become a substantial health and economic burden worldwide. It leads to a variety of metabolic disorders and demands immediate introspection due to its increasing prevalence. The obesity epidemic is progressing worldwide at an alarming scale, and the development of new therapeutic strategiesis of vital importance. One of the key regulators of the whole body energy homeostasis which has become the prime focus of attention as a therapeutic agent for treating obesity is AMP-activated protein kinase (AMPK). The present report discusses the various natural and synthetic compounds that exert antiobesity effects through AMPK mediated mechanisms.