Author(s): Sharma Ankush*, Kanwar Kapil, Singh Amritpal, Pooja and Anju
The colon is a site where both local and systemic delivery of drugs can take place. Local delivery could, for example, allow topical treatment of inflammatory bowel disease. Treatment could be made more effective if it were possible for drugs to be targeted directly on the colon. Colon target drug delivery system has been gained great importance not only for the treatment of local diseases but also for the systemic delivery of proteins, therapeutic peptides, antiasthmatic drugs, antihypertensive drugs and antidiabetic agents. However, recently continuous efforts have been taken on designing colon-specific delivery systems with improved site specificity and versatile drug release kinetics to accomplish different therapeutic needs. The focus of this review is to provide detailed insight into the conventional as well as recent approaches used to target the therapeutic agents specifically to the colon.