Author(s): Deepak Sharma*, Sanjay Kumar Sharma, Manish Jaimini and Amit Kumar
Recent several technical advancements have led to development of various systems that could revolutionize method of drug delivery and hence could provide definite therapeutic benefits. It is an established fact that the conventional immediate release drug delivery systems when taken frequently in a day can maintain drug concentration levels in therapeutically effective range but this result in significant fluctuations in plasma drug levels. The floating or hydro dynamically controlled drug delivery systems namely, floating microspheres, micro beads, microcapsules etc., are useful in overcoming such uncertainty. Micro beads are small, solid and free flowing particulate carriers containing dispersed drug particles. Placing of these DDS in specific region of the GIT offers numerous advantages, specially the drugs having narrow absorption window in GIT, primary absorption in the stomach, stability problem in the intestine, poor solubility at alkaline pH, local activity in stomach, and property to degrade in colon. Recent scientific research has shown increased interest in novel dosage forms that can be retained in the stomach for a prolonged and predictable period of time. The present review deals with the concept, mechanism, recent innovations and applications of multiparticulate drug delivery system.