ISSN: 2249-9504
CAS CODEN: IJPCDX

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Citations : 3566

International Journal of Pharmaceutical, Chemical and Biological Sciences received 3566 citations as per google scholar report

International Journal of Pharmaceutical, Chemical and Biological Sciences peer review process verified at publons

A REVIEW ON CHEMOTHERAPEUTIC ACTIVITIES OF QUINOLINE

Abstract

Author(s): O. Navneetha, K. Deepthi, A. Muralidhar Rao and T. Saritha Jyostna*

Quinoline has emerged as a valuable scaffold in medicinal chemistry possessing diverse range of pharmacological activities. Its value has further been increased by its natural occurrence as alkaloids in variety of plants. The first chemical compound which was a breakthrough for treating the malaria was quinine, an alkaloid isolated from bark of tree cinchona. The main moiety of quinine which exhibited the antimalarial activity was quinoline, on the basis of which later a large number of synthetic quinoline derivatives like chloroquin, amodiaquin, mefloquin were prepared and used as antimalarial agents. Our review is to address the various advances made on quinoline and its derivatives as potent chemotherapeutic agents, this will provide insights for the medicinal chemist for the designing and synthesis of novel quinoline derivatives with novel improved range of pharmacological implications.

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