ISSN: 2249-9504
CAS CODEN: IJPCDX

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Citations : 3566

International Journal of Pharmaceutical, Chemical and Biological Sciences received 3566 citations as per google scholar report

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A FACILE SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF (3-HYDROXY-2,4-DIMETHOXYPHENYL)(PHENYL) METHANONES BY FRIEDEL RAFT?S ACYLATION IN THE PRESENCE OF PHOSPHOROUS PENTOXIDE AND METHANE SULFONIC ACID: EATON?S REAGENT

Abstract

Author(s): Manasa HS, Deepashree CL, Shubha Gopal, Shashikanth S

In the present study, a series of (3-hydroxy-2,4-dimethoxyphenyl)(phenyl) methanones (4a-n), were synthesized by reacting 2, 6-dimethoxy phenol and chloroacetyl chloride by friedel craft’s acylation using eaton’s reagent. The chemical structures of the synthesized compounds were characterized by analytical and spectral (1HNMR, 13CNMR and HRMS) techniques. The title compounds were screened for qualitative (zone of inhibition) and quantitative antimicrobial activity (MIC) by agar well and microbroth dilution technique, respectively. Among the synthesized compounds in the series, the compounds 4k and 4j were found to exhibit significant antibacterial activity at lower concentration, against Gram positive bacteria such as staphylococcus aureus and Gram negative bacteria such as Salmonella typhimurium Escherichia coli, Vibrio typhimurium, Pseudomonas aeruginosa, Klebsiella pneumoniae and Bacillus subtilis. The other compounds displayed moderate antibacterial activity when compared to the standard positive controls Chloramphenicol.

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