ISSN: 2249ā€“9504
CAS CODEN: IJPCDX

A FACILE 1,2,4-OXADIAZOLE DERIVATIVES SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION

Abstract

Author(s): PK. Godhaviya* and PK. Patel

The reaction of benzamidoxime with chloroacetyl chloride in the presence of organic base proceed smoothly under refluxing condition in 2-dichloro ethane to give the corresponding substituted 3-(4- bromo-2-fluorophenyl)-5-(chloromethyl)-1,2,4-oxadiazole. It reacts with different substituted phenol generate a series of novel 1,2,4-oxadiazole compounds. All synthesized compounds were characterized by using elemental analysis, Mass, IR, 1H NMR and 13C NMR spectroscopy. Also compounds were tested for their antibacterial and antifungal activity (MIC) in vitro with two Grampositive bacteria, two Gram-negative bacteria and three fungal strains

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