ISSN: 2249–9504
CAS CODEN: IJPCDX

A COMPARATIVE STUDY ON ANTICANCER POTENTIAL OF DIFFERENT EXTRACTS OF MUCUNA PRURIENS LINN. SEEDS AGAINST SERTOLI (GC) & ZR-75 CELL LINES

Abstract

Author(s): Sanjeev Soni*, Shubha Vaidya, A.K. Jain and Akash Sharma

Mucunapruriens Linn is one of the popular and important medicinal plants of India. In about 200 indigenous drug formulations it has been used as a constituent. The plant is an important cover crop (or green manure crop) in many parts of the world. The plant is commonly known as Common Cowitch, Velvet bean and Cowhage, belonging to the family of Fabaceae and is indigenous to tropical countries like of India and West Indies. In the present study, comparison between the anticancer potential of different extracts of M. Pruriens Linn. Seeds in vitro against sertoli (GC) prostate cancer and ZR-75 breast cancer cell lines was investigated. In the turm of half maximum inhibitory concentration (IC50), or cytotoxicity, cell viability count, and growth inhibition of both cell lines at different concentration of each extracts. The MEMP (IC50-14.74 µg) and PEMP (IC50-15.50 µg) was found more cytotoxic than AEMP (IC50-16.64 µg) against GC cells, but MEMP (IC50-15.06 µg) and AEMP (IC50-15.35 µg) was more cytotoxic than PEMP (IC50- 16.63 µg) against ZR-75 cells. The MTT assay method mainly used in study. The MEMP (15 µg concentration) exhibit significant cell inhibition against both of the cancer cell lines as compare to control after 48, 72 and 96 hrs intervals. The MEMP showed the significant decreased viable tumor cell count and improve tumor cells inhibition and percentage life span. From performed comparative study, exhibited that all extracts have anticancer potential but the MEMP showed significant anticancer potential against GC cells and ZR-75cells and that mean M.pruriens can be used in anticancer activity.

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