ISSN: 2249–9504
CAS CODEN: IJPCDX

UV SPECTROSCOPIC METHOD FOR ESTIMATION OF AMLODIPINE BESYLATE IN TABLETS

Abstract

Author(s): BH. Rajesh Varma1*, Praveen Kumar Jampana2, G. Raveendra Babu3, P. Sri Lakshmi Surekha3, T. Kala Praveen3 and P. Sambhasiva Rao4

A simple, sensitive, specific, and validated UV method has been developed for the quantitative determination of Amlodipine besylate in pure and tablet dosage form. The λmax was found to be 366nm for assay. The linearity was found in concentration range of 5-25 μg/ml. The correlation coefficient was found 0.999. The regression equation was found as Y=0.0238C- 0.0048. The method was validated for linearity, accuracy, precision and ruggedness. The LOD and LOQ for estimation of Amlodipine besylate were found as 0.136, 0.400 respectively. Recovery of Amlodipine besylate was found to be 99.80%.

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