ISSN: 2249–9504
CAS CODEN: IJPCDX

THE EFFECT OF QUERCETIN ON BLOOD GLUCOSE LEVELS OF NORMAL AND STREPTOZOTOCIN INDUCED DIABETIC (TYPE I & TYPE II) RATSKetan Hatware*and A.Annapurna

Abstract

Author(s): Ketan Hatware*and A.Annapurna

This study was conducted to find outthe effect of Quercetin on normal as well as diabetic (Type I & Type II) rats.Wistar strain rats of either sex weighing 150 g -250 g were used for the study. Quercetin was given to normal as well as diabetic (Type I & Type II) rats by oral and intraperitoneal route of administration. Streptozotocin (40 mg/kg IV) was used to induce type I diabetes while Streptozotocin (65 mg/kg IV) and Nicotinamide (150 mg/kg IP ten min prior to dose of Streptozotocin) were used to induce type II diabetes in rats. Rats were fasted for 12 hrs and test (Quercetin) drug was administered by 25 mg/kg oral as well as 10 mg/kg intraperitoneal route and blood glucose levels were estimated by GOD POD method using semi-autoanalyser(Screen Master 3000) at 0 hr, 2ndhr, 4thhr, 6thhr, 8thhr, & 12thhr time intervals. Quercetin has shown significant blood glucose level reduction in normal as well as diabetic (Type I & Type II) rats.The peak reduction in blood glucose level was observed at 8thhr. Hence it was concluded that the Quercetin is having the potential to use in the field of diabetes.

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