Author(s): Damini Puri, Davinder Singh and Monika Gupta*
Antibiotic resistance has been a global healthcare problem due to the indiscriminate use of antibiotics and the subsequent creation of bacteria that can survive traditional treatment. Present research work focused to synthesis of coumarin derivatives. Figure 2 shows synthesis of compounds 8-Methyl-2-substituted-6H-chromeno [6,7-d] oxazol-6-one. All the Molecules were evaluated against Gram positive bacteria Staphylococus aureus (MTCC 3160), Gram negative bacteria E. Coli. (MTCC 614) for antimicrobial activity. The derivative bearing 2-chloro (6f) substituent possessed maximum activity against Gram negative and minimum activity against Gram positive bacteria, whereas 4-chloro (6d) substituent exhibited good activity against both strains.