ISSN: 2249–9504
CAS CODEN: IJPCDX

SYNTHESIS OF NOVEL SUBSTITUTED BENZIMIDAZOLE DERIVATIVES ASPOTENTIAL ANTIMICROBIAL AGENTS

Abstract

Author(s): R.Walia*, K.Dhamija, Vandana, Md J.Akhtar and HS. Lamba

Benzimidazole derivatives play important role in medical field with manypharmacological activities such as antimicrobial, antiviral, antidiabetic and anticanceractivity. The potency of these clinically useful drugs in the treatment of microbial infections andother activities encouraged the development of some more potent and significantcompounds. Benzimidazoles are remarkably effective compounds against variousstrains of microorganisms. This research article is summarized to know about the chemistry ofdifferent derivatives of substituted benzimidazoles along with their pharmacologicalactivities. In the present research the new N-(2-(1H-benzo[d]imidazol-2-yl)phenyl)-N-phenylbenzamide derivatives were synthesised. The reaction was carried out between o-phenylenediamine with substituted anthranilic acids. The resultant compounds were than refluxed with benzoyl chloride in the presence of pyridine to yield the product.The compounds were synthesised in normal yield and their structures were confirmed by IR, H1-NMR spectral data. The antimicrobial activity was evaluated against bacteria and fungi were studied.

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