ISSN: 2249–9504
CAS CODEN: IJPCDX

SYNTHESIS OF NOVEL 2,5-DIHYDRO-1H-1,5-BENZODIAZEPINES ENCOMPASSING NAPHTHO[2,1-B]FURAN AND EVALUATION OF THEIR PHARMACOLOGICALACTIVITIES

Abstract

Author(s): MN. Kumaraswamy, VP. Vaidya*,C. Chandra shekhar, DA. Prathima Mathias, H. Shiva kumar and KM. Mahadevan

The reaction of 2-acetylnaphtho[2,1-b]furan 1with different aromatic aldehydes afforded corresponding chalcones 2(a-f). These chalcones 2(a-f) on reacting with o-phenylenediamine in presence of a base produced 4-(naphtho[2,1-b]furan-2-yl)-2-(substituted)phenyl-2,5-dihydro-1H-1,5-benzodiazepines 3(a-f). The structures of newly synthesized compounds have been established by elemental analysis and spectral studies. Some of the newly synthesized compounds 3a-f exhibited potent antibacterial, antifungal, antiinflammtory, diuretic, anthelmintic and antipyreticactivities.

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