ISSN: 2249-9504
CAS CODEN: IJPCDX

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Citations : 3566

International Journal of Pharmaceutical, Chemical and Biological Sciences received 3566 citations as per google scholar report

International Journal of Pharmaceutical, Chemical and Biological Sciences peer review process verified at publons

SYNTHESIS OF NOVEL 2,5-DIHYDRO-1H-1,5-BENZODIAZEPINES ENCOMPASSING NAPHTHO[2,1-B]FURAN AND EVALUATION OF THEIR PHARMACOLOGICALACTIVITIES

Abstract

Author(s): MN. Kumaraswamy, VP. Vaidya*,C. Chandra shekhar, DA. Prathima Mathias, H. Shiva kumar and KM. Mahadevan

The reaction of 2-acetylnaphtho[2,1-b]furan 1with different aromatic aldehydes afforded corresponding chalcones 2(a-f). These chalcones 2(a-f) on reacting with o-phenylenediamine in presence of a base produced 4-(naphtho[2,1-b]furan-2-yl)-2-(substituted)phenyl-2,5-dihydro-1H-1,5-benzodiazepines 3(a-f). The structures of newly synthesized compounds have been established by elemental analysis and spectral studies. Some of the newly synthesized compounds 3a-f exhibited potent antibacterial, antifungal, antiinflammtory, diuretic, anthelmintic and antipyreticactivities.

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