ISSN: 2249-9504
CAS CODEN: IJPCDX

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Citations : 3566

International Journal of Pharmaceutical, Chemical and Biological Sciences received 3566 citations as per google scholar report

International Journal of Pharmaceutical, Chemical and Biological Sciences peer review process verified at publons

SYNTHESIS OF N'-(CHLOROACETYL)NAPHTHO[2,1-B]FURAN-2- CARBOHYDRAZIDE AND N'-(ARYLAMINOACETYL)NAPHTHO [2,1-B]FURAN-2-CARBOHYDRAZIDE DERIVATIVES AND THEIR ANTIMICROBIAL ACTIVITIES

Abstract

Author(s): DR. Ramesh, KP. Latha* and HM. Vagdevi and MN. Kumaraswamy

The reaction of naphtho[2,1-b]furan-2-carbohydrazide 4 on treatment with chloroacetyl chloride in acid media afforded N'-(chloroacetyl)naphtho[2,1-b]furan-2-carbohydrazide 5. This on treatment with various aryl amines in DMF produced N'-(arylaminoacetyl)naphtho[2,1-b]furan-2- carbohydrazides 6a–f. The structures of 5 and 6a-f have been established by spectral studies. In addition the synthesised compounds have been screened for antimicrobial activities.

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