ISSN: 2249–9504
CAS CODEN: IJPCDX

SYNTHESIS OF N'-(CHLOROACETYL)NAPHTHO[2,1-B]FURAN-2- CARBOHYDRAZIDE AND N'-(ARYLAMINOACETYL)NAPHTHO [2,1-B]FURAN-2-CARBOHYDRAZIDE DERIVATIVES AND THEIR ANTIMICROBIAL ACTIVITIES

Abstract

Author(s): DR. Ramesh, KP. Latha* and HM. Vagdevi and MN. Kumaraswamy

The reaction of naphtho[2,1-b]furan-2-carbohydrazide 4 on treatment with chloroacetyl chloride in acid media afforded N'-(chloroacetyl)naphtho[2,1-b]furan-2-carbohydrazide 5. This on treatment with various aryl amines in DMF produced N'-(arylaminoacetyl)naphtho[2,1-b]furan-2- carbohydrazides 6a–f. The structures of 5 and 6a-f have been established by spectral studies. In addition the synthesised compounds have been screened for antimicrobial activities.

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