Author(s): A. Viswanath*, B. Keerthana, G. HimaBindu, B. Sudha Rani and P. Srinivasa Babu
Benzimidazoles are replaced with a variety of pharmacological activities like anti-hypertensive, antitumor, anti-helmintic along with anti-microbial activity. In this we synthesize various benzimidazole derivatives with the substitution of second position. Ortho phenylenediamine is treated with different substituted aromatic aldehydes in the presence of p-toluene sulphonic acid catalyst. P-TsOHwas used to be a catalyst for the synthesis of 2-arylsubstituted benzimidazoles efficiently. Simple and convenient procedure, easy purification and shorter reaction time are the advantageous features of this method. These synthesized compounds showed significant activity against Gram +ve& Gramve Bacteria.