ISSN: 2249-9504
CAS CODEN: IJPCDX

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Citations : 3566

International Journal of Pharmaceutical, Chemical and Biological Sciences received 3566 citations as per google scholar report

International Journal of Pharmaceutical, Chemical and Biological Sciences peer review process verified at publons

SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL BENZIMIDAZOLE DERIVATIVES

Abstract

Author(s): A. Viswanath*, B. Keerthana, G. HimaBindu, B. Sudha Rani and P. Srinivasa Babu

Benzimidazoles are replaced with a variety of pharmacological activities like anti-hypertensive, antitumor, anti-helmintic along with anti-microbial activity. In this we synthesize various benzimidazole derivatives with the substitution of second position. Ortho phenylenediamine is treated with different substituted aromatic aldehydes in the presence of p-toluene sulphonic acid catalyst. P-TsOHwas used to be a catalyst for the synthesis of 2-arylsubstituted benzimidazoles efficiently. Simple and convenient procedure, easy purification and shorter reaction time are the advantageous features of this method. These synthesized compounds showed significant activity against Gram +ve& Gramve Bacteria.

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